Azithromycin more effective than Doxycycline for Meibomian Gland Dysfunction and Blepharitis. There are several studies concerning the use of topical azithromycin in ocular surface diseases. Dr. Gary Foulks and his group at the University of Louisville compared the effectiveness of topical azithromycin versus oral doxycycline therapy in meibomian gland dysfunction ( Belpharitis) Twenty-two subjects were treated with topical azithromucin solution for one month and seven subjects were treated with oral doxycycline for two months. The study concluded that while both topical azithromycin and oral doxycycline improved clinical signs and symptoms of meibomian gland dysfunction, the “response to azithromycin is more rapid and more robust than doxycycline.”
Yet another study from the Ohio State University School of Optometry evaluated the efficacy of a four-week treatment with topical 1.0% azithromycin solution versus rewetting drops in patients with contact lens related dry eye. An over two-hour improvement in comfortable contact lens wear time was noted throughout the four-week study period with azithromycin solution use.
Blepharitis being a chronic inflammation of the eye lid goes hand in hand with chronic dry eyes.
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